What is alpha tocopherol acetate vitamin E. Alpha tocopherol acetate: instructions for use
Alpha-tocopherol acetate is a vitamin preparation that is used for severe vitamin E deficiency, degenerative changes in the musculoskeletal system, skin diseases, pathologies of the reproductive and endocrine systems, atherosclerosis and other diseases. Unlike low-dose multivitamins, this remedy is not taken for preventive purposes, because the dosage of tocopherol in it is many times higher than the normal daily dose of the vitamin.
Alpha tocopherol acetate is a vitamin preparation that is used for severe vitamin E deficiency and degenerative changes in the musculoskeletal system.
To prevent complications when prescribing a drug, the doctor takes into account not only the indications for its use, but also concomitant pathologies (the patient's medical history).
Release form and composition
Available in the form of an oil solution. For ease of administration, the liquid vitamin preparation is contained in soft capsules or comes complete with a dropper.
Capsules
The most common dosage of tocopherol is 100 mg. The rest of the capsule consists of excipients (glycerol, sunflower oil, gelatin, methyl parahydroxybenzoate, etc.).
Some drugs have a higher dosage of the active ingredient (200 mg or 400 mg).
Capsules are supplied in dark glass bottles or blisters of 10 or 20 pieces.
Solution
A liquid solution of the vitamin, produced in bottles with a dropper, may contain 5%, 10% or 30% of the active substance, i.e. 1 ml of the product corresponds to 50 mg, 100 mg and 300 mg of tocopherol. An auxiliary component of the drug is sunflower oil.
1 ml of product corresponds to 25 drops from the dropper that comes with the bottle. The dose of the drug is calculated taking into account the dosage of tocopherol in 1 drop of solution (2 mg, 4 mg or 12 mg).
1 bottle of the drug contains 20 ml of solution.
Vitamin E is also available in ampoule form, which is intended for intramuscular administration. The concentration of the active ingredient in the injection preparation is similar to its content in the oral solution.
pharmachologic effect
Alpha tocopherol is the most active tocopherol, which compensates for vitamin E deficiency and relieves disorders associated with reduced vitamin E intake.
The main function of this substance is to bind free radicals and inhibit them negative impact on the process of fatty acid oxidation, on vascular walls and other structures and processes. The effectiveness of tocopherol as an antioxidant allows you to slow down the development of atherosclerosis, reduce the oxidation of retinol (vitamin A) and selenium, prevent platelet aggregation and prevent the premature destruction of cell membranes and red blood cells that carry oxygen to tissues.
In addition to antioxidant activity, alpha-tocopherol has the following effects on the body:
- reduces permeability and increases the strength of small blood vessels;
- normalizes the function of the testes, placenta and other reproductive structures;
- reduces the rate of degenerative and dystrophic processes in striated muscles (myocardium, skeletal muscles);
- improves trophism of the heart muscle, skin and other tissues;
- reduces myocardial oxygen demand (acts as an antihypoxant);
- stimulates the production of heme, myoglobin, hemoglobin and other heme-containing substances that provide tissue respiration;
- promotes active synthesis of collagen and functional myocardial proteins;
- increases the body's resistance to infections by stimulating the function of T- and B-lymphocytes;
- reduces the production of low-density lipoproteins (bad cholesterol);
- reduces the toxicity of other fat-soluble vitamins (retinol, calciferol);
- stimulates the restoration of hepatocytes in infectious and non-infectious liver diseases;
- promotes conception, maintenance of pregnancy with a high risk of spontaneous abortion and normal fetal development;
- reduces the incidence of epilepsy attacks.
Indications for use of alpha-tocopherol acetate
Indications for the use of alpha-tocopherol acetate are:
- pathological proliferative and degenerative processes in bone tissue, muscles and ligaments (muscle dystrophy, osteochondrosis, etc.);
- myopathy of traumatic and infectious etiology;
- heart failure, myocardial dystrophy, essential hypertension;
- atherosclerotic vascular damage;
- angina pectoris;
- spasms of peripheral arteries and veins;
- irregularities (including absence) of menstruation, miscarriage;
- hypofunction of the gonads in women and men (including menopause);
- risk of miscarriage;
- dermatomyositis;
- scleroderma;
- systemic lupus erythematosus;
- rheumatoid arthritis (including juvenile);
- dermatological diseases (psoriasis, etc.);
- trophic ulcers with varicose veins and thrombophlebitis;
- asthenia, neurasthenia;
- hemolytic jaundice, hypochromic anemia, malnutrition and other severe developmental disorders in children;
- recovery period after injuries, infectious diseases And surgical intervention, increasing the body's resistance to increased physical activity;
- prevention of the influence of unfavorable radiation and environmental conditions on the body.
Vitamin E is also used as part of a comprehensive drug course for amyotrophic lateral sclerosis, epilepsy, rickets and chronic hepatitis.
An oil solution of tocopherol is actively used in cosmetology: it is added to cosmetical tools(shampoos, balms) and homemade nourishing masks for face and hair.
Contraindications
The use of the drug is contraindicated in case of hypersensitivity to its components, hypervitaminosis E and acute stage myocardial infarction.
In case of cardiosclerosis, a high risk of thrombosis of large vessels, a history of myocardial infarction, hyperthyroidism and bleeding disorders caused by deficiency or impaired metabolism of vitamin K, alpha-tocopherol is prescribed with caution.
How to take alpha tocopherol acetate
Tocopherol solution and capsules are taken orally. The dosage is selected by the attending physician.
Average doses for various pathologies are:
- 50-100 mg (1 capsule, 1-2 ml solution) per day for hypovitaminosis E, chronic hepatitis, degenerative changes in muscles and bones, skin diseases, convalescence after serious illnesses and operations;
- 300-400 mg 1 time every 2 days, from the 17th day of the cycle until the onset of menstruation in case of disturbances hormonal levels and reproductive function in women;
- 100-300 mg per day for decreased sperm production and potency in men;
- 100-150 mg every 1-2 days with an increased risk of miscarriage and disorders of the child’s intrauterine development;
- 100 mg per day for dystrophy of cardiac muscle tissue, atherosclerotic lesions and pathologies of peripheral vessels;
- 5-10 mg (1-2 drops of a 10% solution) per day for pathologies of the hematopoietic organs, joints and bones in newborns.
At high physical activity Tocopherol preparations are prescribed in a dose not exceeding 50-100 mg per day.
The duration of the course of treatment can range from 1-2 weeks to 1.5-2 months. The longest therapy is prescribed for disturbances in the normal course of pregnancy and pathologies of the musculoskeletal system and the cardiovascular system.
When used for cosmetic purposes, the duration of use is not limited. To fortify 1 serving of shampoo, mask or balm with vitamin E, you need 1-2 drops of a 5-10% oil solution of tocopherol.
Side effects of alpha-tocopherol acetate
The following side effects may occur during alpha-tocopherol therapy:
- allergic reactions;
- nausea, abdominal pain (in the epigastric region), diarrhea;
- liver enlargement;
- increased risk of vascular thromboembolism;
- decreased performance;
- weakness, fatigue, dizziness;
- cephalgia;
- visual impairment;
- decreased blood clotting;
- changes in the results of biochemical blood and urine tests (increased creatinine, creatine phosphokinase and cholesterol).
Injection of the solution is a rather painful procedure. In some cases, infiltrates occur at the injection site.
When applied to the face and scalp without an allergy test, local allergic reactions (redness, itching, etc.) may develop.
Overdose
Subject to the recommended dosage of the drug adverse reactions rarely develop. To avoid an overdose, you should not take a double dose if you miss a dose, increase the duration of the course without a doctor’s prescription, and take multivitamin complexes that contain vitamin E.
Long-term use of tocopherol in a daily dose of 400-800 mg can cause blurred vision, severe diarrhea, fainting and other pathological phenomena.
Ultra-high doses of the drug (more than 800 mg) can provoke metabolic disorders of iodine-containing hormones, pulmonary embolism, internal bleeding, hemorrhages in the brain and retina, sexual function disorders, ascites, hyperbilirubinemia, necrotizing colitis and sepsis. In rare cases, with an overdose of tocopherol, it develops renal failure.
Vitamin E accumulates well in the body, so the toxic effects of the drug may persist even after cessation of therapy.
There is no specific antidote for tocopherol. In case of overdose, discontinuation of drug therapy, relief of dysfunction of internal organs and administration of glucocorticosteroids are indicated.
special instructions
In epidermolysis bullosa, tocopherol therapy can cause active growth of white hair in areas of alopecia.
Use during pregnancy and lactation
During pregnancy and breastfeeding any pharmacological forms vitamin E are taken strictly according to the recommendation of the attending physician.
During normal pregnancy, tocopherol monotherapy is not used, because the dose of the vitamin during pregnancy should not exceed 10-14 mg per day.
Use in children
Vitamin E should be given to children strictly as prescribed by the attending physician. It is mainly used in the treatment of patients under 18 years of age. oil solution, which allows you to accurately dose the active component.
The dosage of the medicine is selected according to age and diagnosis.
Drug interactions
Alpha-tocopherol acetate interacts with other drugs as follows:
- enhances the effect of corticosteroids, NSAIDs, anticonvulsants and cardiac glycosides;
- increases the effectiveness and reduces the toxicity of rutin (vitamin P), retinol (vitamin A) and calciferol (vitamin D3);
- interferes with the absorption of vitamin K, slows down the absorption of iron and increases the effectiveness of indirect anticoagulants (with a daily dose of more than 400 mg);
- enhances the antioxidant effect of selenium.
Lipid-lowering drugs (Colestipol, Cholestyramine) and mineral oils reduce the absorption of tocopherol.
Vitamin E should not be prescribed simultaneously with silver preparations and alkaline-reactive substances.
Terms and conditions of storage
The shelf life of the solution, subject to storage rules, is 2 years, and capsules - 3 years.
Conditions for dispensing from pharmacies
Alpha-tocopherol acetate is available without a prescription.
Price
The cost of the drug is from 31 rubles. for 20 ml of solution and from 24 rubles. for 10 capsules (the dosage of both products is 100 mg).
Analogs
Analogues of alpha-tocopherol acetate are:
- Vitamin E Nutricology (active ingredient - alpha-tocopherol succinate);
- Aekol;
- Aevit;
- Vitamin E Zentiva;
- Vitrum Vitamin E and others.
Alpha tocopheryl acetate is a fat-soluble vitamin E that is a natural antioxidant.
Composition, release form and analogues
Alpha-tocopherol acetate is available in the form of capsules and an oily solution for injection, as well as a solution for oral administration. The active ingredient in all forms is vitamin E (100 mg). The excipient in Alpha-tocopherol acetate capsules is soybean oil.
The capsule shells also contain methyl parahydroxybenzoate, glycerol and gelatin. The solution of the drug for oral administration, in addition to the main component in the form of vitamin E, contains refined sunflower oil, sometimes deodorized.
Alpha tocopherol acetate capsules are spherical in shape and red in color. They are filled with a light or dark yellow liquid and do not have a rancid odor. One capsule – 0.5 g. Glass jar contains 15 pieces.
An oil solution of Alpha-tocopherol acetate 5 or 10% for intramuscular injection is produced in ampoules of 1 ml. One cardboard package contains 10 ampoules. For oral administration, a 50% solution of the drug is used, which is an oily liquid of a light or dark yellow hue without a rancid odor. It can sometimes have a greenish tint.
Among the analogues of Alpha-tocopherol acetate, the following drugs should be highlighted:
- Adaptovit;
- Biovital Vitamin E;
- Vitamin E;
- Vitamin E Zentiva;
- Vitrum Vitamin E;
- Sant-E-gal;
- Evitol;
- Tocopherol acetate.
Pharmacological action of Alpha-tocopherol acetate
Vitamin E is a natural antioxidant and protects against oxidative processes cell membranes body tissues. It also organizes stimulation of the synthesis of heme-containing enzymes, which include myoglobin, catalase, hemoglobin, and cytochromes. Vitamin Alpha Tocopherol Acetate is a vital component for proper operation nervous and muscular systems. It plays the role of a cofactor in certain enzyme systems, as it prevents the oxidation of unsaturated fatty acids. This is due to the property of the vitamin in combination with selenium to inhibit the hemolysis of red blood cells.
It is important to note that the lack of vitamin Alpha-tocopherol acetate in the body greatly affects changes in skeletal muscles and in tissue structures, which can often lead to irreversible consequences. Its deficiency sometimes provokes fragility and increased capillary permeability, as well as damage to liver cells and nerve tissue.
Alpha tocopherol acetate compensates for the lack of vitamin E in the body. It prevents dysfunction of the testicles, seminal canals and placenta, and helps normalize reproductive function. The drug improves contractility and nutrition of the myocardium, and also leads to a decrease in oxygen consumption by the myocardium. Vitamin Alpha-tocopherol acetate helps stimulate the synthesis of proteins (structural, enzymatic and contractile proteins of the myocardial muscles) and improves tissue respiration.
Indications for use of Alpha-tocopherol acetate
According to the instructions for Alpha-tocopherol acetate, this medication is used primarily for degenerative changes in the ligamentous apparatus, muscular dystrophy and hypovitaminosis. The drug is often prescribed after various diseases occurring with febrile syndrome. Alpha-tocopherol acetate capsules and oil solution for injection are often used to treat hypofunction of the gonads in men, as well as threatened abortion, menopause, and dysmenorrhea.
According to the instructions for Alpha-tocopherol acetate, it is also used in the following cases:
- Neurasthenia;
- Atherosclerosis;
- Rheumatoid arthritis;
- Neurasthenic and asthenic syndromes;
- Overwork;
- Peripheral vascular spasms.
Alpha tocopherol acetate is also used in pediatrics. It is prescribed to children for eating disorders and scleroderma (a systemic skin disease). In addition, the drug is used as an antioxidant in the treatment of cardiovascular and eye diseases.
Contraindications
According to the instructions for alpha-tocopherol acetate, this medication is contraindicated in cases of hypersensitivity to its components, myocardial infarction and cardiosclerosis.
Method of use of Alpha-tocopherol acetate
The daily dose of the drug for diseases of the nervous and muscular systems is 50-100 mg. For peripheral vascular diseases and atherosclerosis - 100 mg, potency disorders - 100-300 mg.
If there is a threat of miscarriage, 100-150 mg is prescribed daily for a month. In the first trimester of pregnancy - 100-150 mg in cases of deterioration of the embryo's condition.
Side effects
Alpha-tocopherol acetate in rare cases can cause allergic reactions in the form of rash, itching and flushing of the skin. If the course of treatment is designed for for a long time, the following side effects are possible:
- Weakness of the body;
- Diarrhea;
- Increased fatigue;
- Constipation;
- Headache;
- Nausea;
- Dysfunction of the gonads.
And in cases of dose abuse, concomitant manifestations such as visual impairment, painful sensations in the head and dizziness, as well as epigastric pain and indigestion.
Alpha-tocopherol acetate drug interactions
Alpha-tocopherol acetate should not be used orally with anticoagulants. indirect action, as well as with silver and iron preparations. The drug can increase the effectiveness of anticonvulsants in patients suffering from epilepsy and the effect of non-steroidal anti-inflammatory drugs.
Taking the medication reduces the toxic effect of cardiac glycosides. It promotes the absorption of retinol, but has an antagonistic effect on vitamin K.
Storage conditions
Alpha tocopherol acetate should be stored in a dry place at a temperature of 15-25°C. The shelf life is 2 years.
Instructions
for medical use
medicine
Alpha tocopherol acetate (vitamin E) solution in oil 50%
Tradename
Alpha tocopherol acetate (vitamin E) solution in oil 50%
International nonproprietary name
Tocopherol
Compound
One capsule contains
active substance- vitamin E (dl-alpha-tocopherol acetate) - 100 mg
Excipients: refined sunflower oil,
shell composition: gelatin, glycerin, nipagin, dye (karmazin E 122), purified water.
Description
The spherical capsules are red in color, without streaks or mechanical impurities. The contents of the capsule are an oily liquid from light yellow to dark yellow.
Pharmacotherapeutic group
Other vitamins.
ATS code A11NA03
Pharmacological properties
Pharmacokinetics
Tocopherol is slowly absorbed from the gastrointestinal tract, approximately 50%, the maximum level in the blood is created after 4 hours. Absorption requires the presence of bile acids. During absorption, it forms a complex with lipoproteins, which are intracellular carriers of vitamin E. It enters mainly into the lymph, then into the general bloodstream, where it binds mainly with alpha and beta lipoproteins, and partially with serum albumin. When protein metabolism is disrupted, transport becomes difficult. Deposited in the adrenal glands, pituitary gland, testes, adipose and muscle tissues, red blood cells, and liver. Tocopherol is metabolized in tissues with the formation of quinone compounds, similar in structure to coenzyme Q. 70% of the taken dose of tocopherol is excreted in the bile. The other part is excreted through the kidneys in the form of glucuronic conjugates. It remains in the body for a relatively short time, so it needs constant replenishment.
Pharmacodynamics
It has antioxidant activity, since it contains a phenolic ring with a system of conjugated double bonds; it easily donates an electron to free radicals, reducing them to stable products. The phenoxyl radical that is formed in this case is quite stable in itself and does not participate in the continuation of the chain. Alpha tocopherol is involved in the processes of tissue metabolism, prevents hemolysis of red blood cells, increased permeability and fragility of capillaries, dysfunction of the seminiferous tubules and testicles, placenta, normalizes reproductive function; prevents the development of atherosclerosis, degenerative-dystrophic changes in the heart muscle and skeletal muscles, improves the nutrition and contractility of the myocardium, and reduces myocardial oxygen consumption. Inhibits free radical reactions, prevents the formation of peroxides that damage cellular and subcellular membranes. Stimulates the synthesis of hemoglobin, myoglobin and cytochromes, as well as the synthesis of calcium ATPase, catalase, peroxidase. Improves tissue respiration, stimulates the synthesis of proteins (collagen, enzymatic, structural and contractile proteins of skeletal and smooth muscles, myocardium), protects vitamin A from oxidation. Inhibits the oxidation of unsaturated fatty acids and selenium (a component of the microsomal electron transfer system). Inhibits cholesterol synthesis.
Indications for use
In case of dysfunction of the gonads in men
In women with a threat of miscarriage and various disorders menstrual cycle, when the conditions of intrauterine development of the fetus worsen
At muscular dystrophies, amyotrophic lateral sclerosis, dermatomyositis and other collagenoses
For lesions of peripheral vessels (endoarteritis, Raynaud's disease), myocardial dystrophy, atherosclerosis
For seborrhea, atrophic skin changes (scleroderma and others), trophic ulcers of the leg, photodermatoses
Directions for use and doses
Inside, during or after meals, with a small amount of water.
If spermatogenesis and potency are impaired, men are prescribed 100-300 mg of Alpha tocopherol acetate per day (in combination with hormonal therapy) for a month.
In case of threatened abortion - 100-150 mg per day for 7-14 days; in case of habitual abortion and worsening conditions of intrauterine development of the fetus - 100-150 mg per day, in the first 2-3 months of pregnancy daily or every other day.
For muscular dystrophies, amyotrophic lateral sclerosis, dermatomyositis and other collagenoses, 15-100 mg per day for 1-2 months; Repeated courses are prescribed after 2-3 months.
For peripheral vascular diseases, myocardial dystrophy, atherosclerosis, 100 mg per day is prescribed (in combination with vitamin A) for 20-40 days; after 3-6 months, the course of treatment can be repeated.
For skin diseases, the drug is prescribed from 15 to 100 mg per day for 20-40 days.
Side effects
Allergic reactions
When taken in high doses- diarrhea, epigastric pain
Contraindications
Hypersensitivity to the components of the drug
Cardiosclerosis, acute heart attack myocardium
Children under 18 years of age
Drug interactions
Increases the effectiveness of anticonvulsants (increased levels of lipid peroxidation products in the blood), steroidal and non-steroidal anti-inflammatory drugs, and anticoagulants. Combination with vitamins A, D and cardiac glycosides helps to increase efficiency and reduce their toxicity.
Iron increases daily requirement in vitamin E. Vitamin E in a dose exceeding 400 IU per day enhances the effect of anticoagulants.
Prescribing vitamin E in high doses can cause vitamin A deficiency in the body.
Simultaneous use of vitamin E in a dose of more than 400 IU per day with anticoagulants (coumarin and indanedione derivatives) increases the risk of hypothrombinemia and bleeding.
Cholestyramine, colestipol, and mineral oils reduce the absorption of vitamin E.
special instructions
Carefully- in patients with an increased risk of developing thromboembolism; Hypoprothrombinemia caused by vitamin K deficiency may be worsened by vitamin E doses greater than 400 IU.
Pregnancy and lactation
During pregnancy and breastfeeding, take the drug only on the recommendation of a doctor.
Features of the effect of the drug on the ability to drive vehicle or potentially dangerous mechanisms
Does not affect.
Overdose
Complications of hypervitaminosis E are associated with:
Excessive inhibition of free radical reactions in neutrophils and
other phagocytes (digestion of captured microorganisms is impaired,
what can manifest as sepsis)
oily oral solution 5%, 10% and 30%
Registration number: P N001153/01
Tradename:α-Tocopherol acetate.
International nonproprietary name: alpha tocopherol acetate
Dosage form: oral solution [oil]
Description
Transparent oily liquid from light yellow to dark yellow color without rancid odor. A greenish tint is allowed.
Compound
Active substance: Vitamin E (α-Tocopherol acetate) – 50 g, 100 g and 300 g;
Excipients– sunflower oil (refined deodorized sunflower oil) – up to 1 liter.
Pharmacotherapeutic group: vitamin
ATH CODE:[A11NA03]
Pharmacological properties
Vitamin E is a natural antioxidant. Protects cell membranes of body tissues from oxidative changes; stimulates the synthesis of heme and heme-containing enzymes - hemoglobin, myoglobin, cytochromes, catalase, peroxidase. Inhibits the oxidation of unsaturated fatty acids and selenium. Inhibits cholesterol synthesis. Prevents hemolysis of red blood cells, increased permeability and fragility of capillaries, dysfunction of seminiferous tubules and testicles, placenta, normalizes reproductive function; prevents the development of atherosclerosis, degenerative-dystrophic changes in the heart muscle and skeletal muscles.
Indications for use
Hypovitaminosis E; complex therapy of conditions accompanied by an increased need for vitamin E:
for muscular dystrophies, dermatomycosis, amyotrophic lateral sclerosis, asthenic and neurasthenic syndromes, fatigue, paresis, myasthenia gravis, myopathies, menstrual irregularities, threat of miscarriage, menopause, dysfunction of the gonads in men and women;
for dermatoses, psoriasis;
with atrophy of the mucous membrane of the respiratory tract, periodontal disease;
for rheumatic diseases: fibrositis, tendinopathy, diseases of the joints and spine;
for endocrine diseases: thyrotoxicosis, diabetes mellitus, especially ketoacidosis, diabetic polyneuropathy;
with malabsorption syndrome, chronic liver diseases;
with myocardial dystrophy, spasms of peripheral vessels.
In a state of convalescence after illnesses that occurred with a febrile syndrome.
Contraindications
Increased individual sensitivity to the drug.
With caution: hypoprothrombinemia (due to vitamin K deficiency - may increase with a dose of vitamin E more than 400 IU), severe atherosclerosis of the coronary arteries, myocardial infarction, increased risk of thromboembolism.
Directions for use and doses
For oral administration, the drug is prescribed in the following doses:
For diseases of the neuromuscular system (myodystrophy, amyotrophic lateral sclerosis, etc.) 50-100 mg per day (50-100 drops of a 5% solution, 25-30 drops of a 10% solution or 7-15 drops of a 30% solution) for 1- 2 months. Repeated courses after 2-3 months.
For men with disorders of spermatogenesis and potency, 100-300 mg per day (100-300 drops of a 5% solution, 50-150 drops of a 10% solution or 15-46 drops of a 30% solution) in combination with hormonal therapy for a month.
For threatened abortion, 100-150 mg per day (100-150 drops of a 5% solution, 50-75 drops of a 10% solution or 15-23 drops of a 30% solution).
In case of habitual abortion and deterioration of intrauterine development of the fetus, 100-150 mg per day (100-150 drops of a 5% solution, 50-75 drops of a 10% solution or 15-23 drops of a 30% solution) in the first 2-3 months of pregnancy daily or every other day.
For peripheral vascular diseases, myocardial dystrophy, atherosclerosis, 100 mg per day (100 drops of a 5% solution, 50 drops of a 10% solution or 15 drops of a 30% solution) in combination with vitamin A. Course duration 20-40 days, after 3-6 months the course of treatment can be repeated.
For skin diseases, from 15 to 100 mg per day (15-100 drops of a 5% solution, 7-50 drops of a 10% solution or 2-5 drops of a 30% solution) for 20-40 days.
1 drop from an eye pipette contains: α - Tocopherol acetate in a 5% solution – 1 mg, in a 10% solution – 2 mg; in a 30% solution – 6.5 mg.
Side effect
Allergic reactions. The use of large doses of the drug can cause dyspeptic disorders, decreased performance, weakness, thrombophlebitis, pulmonary embolism, thrombosis, increased creatine kinase activity, creatinuria, hypercholesterolemia, white hair growth in areas of alopecia with epidermolysis vesicularis.
Overdose
Symptoms: when taken for a long period in doses of 400-800 IU / day (1 mg = 1.21 IU) – vagueness visual perception, dizziness, headache, nausea, unusual fatigue, diarrhea, gastralgia, asthenia, when taking more than 800 IU/day for a long period - increased risk of bleeding in patients with hypovitaminosis K, impaired metabolism of thyroid hormones, disorders of sexual function, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, retinal hemorrhage, hemorrhagic stroke, ascites.
Treatment: symptomatic, drug withdrawal, administration of glucocorticosteroid drugs.
Interaction with other drugs
Enhances the effect of glucocorticosteroid drugs, non-steroidal anti-inflammatory drugs, antioxidants.
Increases the effectiveness and reduces the toxicity of vitamins A, D, cardiac glycosides.
Prescribing vitamin E in high doses can cause vitamin A deficiency in the body.
Increases the effectiveness of antiepileptic drugs medicines in patients with epilepsy (who have increased levels of lipid peroxidation products in the blood).
Simultaneous use of vitamin E in a dose of more than 400 IU/day with anticoagulants (coumarin and indandione derivatives) increases the risk of developing hypoprothrombinemia and bleeding.
Cholestyramine, colestipol, and mineral oils reduce absorption.
High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.
special instructions
From the generally accepted designation used in the food industry - E307 synthetic alpha-tocopherol - a natural conclusion arises about the artificial route of obtaining this substance.
The main function of E307 is to protect the color of food as a result of various processes of oxidation and, as a result, spoilage. The substance E307 is an oil-based liquid that does not tolerate sunlight and exposure to air masses.
This substance is an analogue, which in the natural environment can be found in eggs, oils, wheat germ and other cereals, and meat products. Vegetable oils are used as raw materials for the production of synthetic alpha-tocopherol.
Application of dietary supplement
Alpha tocopherol is used extensively in food production. The substance has proven itself excellent in those foods that contain a lot of oils, since alpha tocopherol can significantly prolong the shelf life of any prepared food.
Food antioxidant E307 is absolutely freely approved for use in the European Union, Ukraine, Russia to improve the quality and shelf life of fats and oils, acting in such food formulas not only as an antioxidant, but also as an important source of vitamin E that enriches food. The additive is approved for use even in infant formulas, which is very rare.
Thanks to this fortified effect of E307, alpha-tocopherol is widely used in the pharmaceutical industry - here the substance is actively added to vitamin complexes and other medicines.
Synthetic alpha-tocopherol is also used in the cosmetics industry, as it serves as an excellent vitamin supplement numerous creams, masks, oils and ointments.
Useful qualities of synthetic alpha-tocopherol
At its core, the food antioxidant alpha-tocopherol is synthetic or food supplement with index E307 is vitamin E with all that it implies beneficial properties for the human body.
The antioxidant is able to effectively prevent the destructive effects of free radicals on human health, and also prevents the oxidation of fats in the body.
However, the main thing positive factor for humans, when using food products based on alpha-tocopherol as food, it is its regulatory ability regarding the cellular uptake of oxygen.
This factor contributes to the fact that the substance E307 is recommended for use by those people who have been diagnosed with a lack of oxygen, diabetes, hypertension, numerous diseases of the cardiovascular system, malignant tumors(oncological diseases).
Synthetic vitamin E actively stimulates the functioning of mitochondria, which are responsible for synthesizing the energy that the body's cells use in their own life.
This quality of alpha-tocopherol is very useful in the treatment of cancer, during which the work of the affected organs is severely impaired and the body does not have enough strength and energy to restore it.
An antioxidant used in food, E307 serves as a beneficial vitamin complex for the human reproductive system.
If there is a lack of vitamin E in the body of a pregnant woman, fetal development may be impaired. The male body, with the same lack of synthetic alpha-tocopherol, becomes infertile or incapable of fertilization. Also, the synthetic additive E307 significantly reduces the risk of miscarriages during pregnancy.
The most common symptom of a lack of vitamin E or alpha-tocopherol in cells is severe muscle weakness.
This condition is often observed in patients with cancer. Medicine has not found any other external signs that a person lacks vitamin E, so such a deficiency is very difficult to diagnose. During such a shortage, the body actually suffers a lot.
Thus, the main functional benefit of the synthetic alpha-tocopherol antioxidant E307 is its ability to restore natural absorption in the body and prevent a lack of oxygen in body cells. This is why doctors most often prescribe medicinal vitamin A together with synthetic alpha-tocopherol.
Necessary norm daily consumption substance is an indicator of 20-40 milligrams of tocopherol for each person.