The number of chromosomes in different types of living organisms. DNA record holders: how the genomes of humans and worms relate to each other

Did Charles Darwin renounce his theory of human evolution at the end of his life? Did ancient people find dinosaurs? Is it true that Russia is the cradle of humanity, and who is the yeti - perhaps one of our ancestors, lost through the centuries? Although paleoanthropology - the study of human evolution - is booming, the origins of man are still surrounded by many myths. These are anti-evolutionist theories, and legends generated by mass culture, and pseudo-scientific ideas that exist among educated and well-read people. Do you want to know how everything “really” was? Alexander Sokolov, editor-in-chief of the portal ANTHROPOGENES.RU, collected a whole collection of similar myths and checked how valid they are.

At the level of everyday logic, it is obvious that “a monkey is cooler than a person - it has two whole more chromosomes!” Thus, “the origin of man from the ape is finally refuted”...

Let us remind our dear readers that chromosomes are the things in which DNA is packaged in our cells. Humans have 23 pairs of chromosomes (23 we got from our mom and 23 from our dad. Total is 46). The complete set of chromosomes is called a "karyotype". Each chromosome contains a very large DNA molecule, tightly coiled.

It is not the number of chromosomes that is important, but the genes that these chromosomes contain. The same set of genes can be packaged into different numbers of chromosomes.

For example, two chromosomes were taken and merged into one. The number of chromosomes has decreased, but the genetic sequence they contain remains the same. (Imagine that a wall was broken between two adjacent rooms. The result is one large room, but the contents - furniture and parquet flooring - are the same...)

The fusion of chromosomes occurred in our ancestor. This is why we have two fewer chromosomes than chimpanzees, despite the fact that the genes are almost the same.

How do we know about the similarity of human and chimpanzee genes?

In the 1970s, when biologists learned to compare the genetic sequences of different species, they did this for humans and chimpanzees. The specialists were in for a shock: “ The difference in the nucleotide sequences of the substance of heredity - DNA - in humans and chimpanzees as a whole amounted to 1.1%,– wrote the famous Soviet primatologist E.P. Friedman in the book “Primates”. -... Species of frogs or squirrels within the same genus differ from each other 20–30 times more than chimpanzees and humans. This was so surprising that it was urgently necessary to somehow explain the discrepancy between the molecular data and what is known at the level of the whole organism» .

And in 1980, in a reputable magazine Science An article by a team of geneticists at the University of Minneapolis was published, The Striking Resemblance of High-Resolution G-Banded Chromosomes of Man and Chimpanzee (“Striking similarity of high-resolution stained chromosome bands of humans and chimpanzees”).

The researchers used the latest chromosome coloring methods at that time (transverse stripes of different thicknesses and brightness appear on the chromosomes; each chromosome has its own special set of stripes). It turned out that in humans and chimpanzees the chromosome striations are almost identical! But what about the extra chromosome? It’s very simple: if, opposite the second human chromosome, we put the 12th and 13th chimpanzee chromosomes in one line, connecting them at their ends, we will see that together they make up the second human chromosome.

Later, in 1991, researchers took a closer look at the point of the putative fusion on the second human chromosome and found there what they were looking for - DNA sequences characteristic of telomeres - the end sections of chromosomes. Another proof that in place of this chromosome there were once two!

But how does such a merger happen? Let's say that one of our ancestors had two chromosomes combined into one. He ended up with an odd number of chromosomes - 47, while the rest of the non-mutated individuals still had 48! And how did such a mutant then reproduce? How can individuals with different numbers of chromosomes interbreed?

It would seem that the number of chromosomes clearly distinguishes species from each other and is an insurmountable obstacle to hybridization. Imagine the surprise of the researchers when, while studying the karyotypes of various mammals, they began to discover variations in the number of chromosomes within some species! Thus, in different populations of the common shrew this figure can range from 20 to 33. And the varieties of the musk shrew, as noted in the article by P. M. Borodin, M. B. Rogacheva and S. I. Oda, “differ from each other more than humans from chimpanzees: animals living in the south of Hindustan and Sri Lanka , have 15 pairs of chromosomes in their karyotype, and all other shrews from Arabia to the islands of Oceania have 20 pairs... It turned out that the number of chromosomes decreased because five pairs of chromosomes of a typical variety merged with each other: 8th with 16th, 9? I’m from 13th, etc.”

Mystery! Let me remind you that during meiosis - cell division, which results in the formation of sex cells - each chromosome in the cell must connect with its homologue pair. And then, when fused, an unpaired chromosome appears! Where should she go?

It turns out that the problem is solved! P. M. Borodin describes this process, which he personally recorded in 29-chromosomal punares. Punare are bristly rats native to Brazil. Individuals with 29 chromosomes were obtained by crossing between 30- and 28-chromosomal punares belonging to different populations of this rodent.

During meiosis in such hybrids, paired chromosomes successfully found each other. “And the remaining three chromosomes formed a triple: on the one hand, a long chromosome received from the 28-chromosomal parent, and on the other, two shorter ones, which came from the 30-chromosomal parent. At the same time, each chromosome fell into place"

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​What mutations, besides Down syndrome, threaten us? Is it possible to cross a man with a monkey? And what will happen to our genome in the future? The editor of the portal ANTHROPOGENES.RU talked about chromosomes with a geneticist, head. lab. comparative genomics SB RAS Vladimir Trifonov.

− Can you explain in simple language what a chromosome is?

− A chromosome is a fragment of the genome of any organism (DNA) in complex with proteins. If in bacteria usually the entire genome is one chromosome, then in complex organisms with a pronounced nucleus (eukaryotes) the genome is usually fragmented, and complexes of long fragments of DNA and protein are clearly visible in a light microscope during cell division. That is why chromosomes as colorable structures (“chroma” - color in Greek) were described at the end of the 19th century.

− Is there any relationship between the number of chromosomes and the complexity of an organism?

- There is no connection. The Siberian sturgeon has 240 chromosomes, the sterlet has 120, but it is sometimes quite difficult to distinguish these two species from each other based on external characteristics. Female Indian muntjac have 6 chromosomes, males have 7, and their relative, the Siberian roe deer, has more than 70 (or rather, 70 chromosomes of the main set and up to a dozen additional chromosomes). In mammals, the evolution of chromosome breaks and fusions proceeded quite intensively, and now we are seeing the results of this process, when each species often has characteristic features of its karyotype (set of chromosomes). But, undoubtedly, the general increase in genome size was a necessary step in the evolution of eukaryotes. At the same time, how this genome is distributed into individual fragments does not seem to be very important.

− What are some common misconceptions about chromosomes? People often get confused: genes, chromosomes, DNA...

− Since chromosomal rearrangements do occur frequently, people have concerns about chromosomal abnormalities. It is known that an extra copy of the smallest human chromosome (chromosome 21) leads to a rather serious syndrome (Down syndrome), which has characteristic external and behavioral features. Extra or missing sex chromosomes are also quite common and can have serious consequences. However, geneticists have also described quite a few relatively neutral mutations associated with the appearance of microchromosomes, or additional X and Y chromosomes. I think the stigmatization of this phenomenon is due to the fact that people perceive the concept of normal too narrowly.

− What chromosomal mutations occur in modern humans and what do they lead to?

− The most common chromosomal abnormalities are:

− Klinefelter syndrome (XXY men) (1 in 500) – characteristic external signs, certain health problems (anemia, osteoporosis, muscle weakness and sexual dysfunction), sterility. There may be behavioral features. However, many symptoms (except sterility) can be corrected by administering testosterone. Using modern reproductive technologies, it is possible to obtain healthy children from carriers of this syndrome;

− Down syndrome (1 in 1000) – characteristic external signs, delayed cognitive development, short life expectancy, may be fertile;

− trisomy X (XXX women) (1 in 1000) – most often there are no manifestations, fertility;

− XYY syndrome (men) (1 in 1000) – almost no manifestations, but there may be behavioral characteristics and possible reproductive problems;

− Turner syndrome (women with CP) (1 in 1500) – short stature and other developmental features, normal intelligence, sterility;

− balanced translocations (1 in 1000) – depends on the type, in some cases developmental defects and mental retardation may be observed and may affect fertility;

− small additional chromosomes (1 in 2000) – the manifestation depends on the genetic material on the chromosomes and varies from neutral to serious clinical symptoms;

Pericentric inversion of chromosome 9 occurs in 1% of the human population, but this rearrangement is considered a normal variant.

Is the difference in the number of chromosomes an obstacle to crossing? Are there any interesting examples of crossing animals with different numbers of chromosomes?

− If the crossing is intraspecific or between closely related species, then the difference in the number of chromosomes may not interfere with crossing, but the descendants may turn out to be sterile. There are a lot of hybrids known between species with different numbers of chromosomes, for example, equines: there are all kinds of hybrids between horses, zebras and donkeys, and the number of chromosomes in all equines is different and, accordingly, hybrids are often sterile. However, this does not exclude the possibility that balanced gametes may be produced by chance.

- What unusual things have been discovered recently in the field of chromosomes?

− Recently, there have been many discoveries regarding the structure, function and evolution of chromosomes. I especially like the work that showed that sex chromosomes were formed completely independently in different groups of animals.

- Still, is it possible to cross a man with a monkey?

- Theoretically, it is possible to obtain such a hybrid. Recently, hybrids of much more evolutionarily distant mammals (white and black rhinoceros, alpaca and camel, and so on) have been obtained. The red wolf in America has long been considered a separate species, but has recently been proven to be a hybrid between a wolf and a coyote. There are a huge number of feline hybrids known.

- And a completely absurd question: is it possible to cross a hamster with a duck?

- Here, most likely, nothing will work out, because too many genetic differences have accumulated over hundreds of millions of years of evolution for the carrier of such a mixed genome to function.

- Is it possible that in the future a person will have fewer or more chromosomes?

- Yes, this is quite possible. It is possible that a pair of acrocentric chromosomes will merge and such a mutation will spread throughout the population.

− What popular science literature do you recommend on the topic of human genetics? What about popular science films?

− Books by biologist Alexander Markov, the three-volume “Human Genetics” by Vogel and Motulsky (though this is not science-pop, but there is good reference data there). Nothing comes to mind from films about human genetics... But Shubin’s “Inner Fish” is an excellent film and book of the same name about the evolution of vertebrates.

B chromosomes have not yet been discovered in humans. But sometimes an additional set of chromosomes appears in cells - then they talk about polyploidy, and if their number is not a multiple of 23 - about aneuploidy. Polyploidy occurs in certain types of cells and contributes to their increased work, while aneuploidy usually indicates disturbances in the functioning of the cell and often leads to its death.

We must share honestly

Most often, an incorrect number of chromosomes is a consequence of unsuccessful cell division. In somatic cells, after DNA duplication, the maternal chromosome and its copy are linked together by cohesin proteins. Then kinetochore protein complexes sit on their central parts, to which microtubules are later attached. When dividing along microtubules, kinetochores move to different poles of the cell and pull chromosomes with them. If the crosslinks between copies of a chromosome are destroyed ahead of time, then microtubules from the same pole can attach to them, and then one of the daughter cells will receive an extra chromosome, and the second will remain deprived.

Meiosis also often goes wrong. The problem is that the structure of linked two pairs of homologous chromosomes can twist in space or separate in the wrong places. The result will again be an uneven distribution of chromosomes. Sometimes the reproductive cell manages to track this so as not to pass the defect on to inheritance. The extra chromosomes are often misfolded or broken, which triggers the death program. For example, among spermatozoa there is such selection for quality. But the eggs are not so lucky. All of them are formed in humans even before birth, prepare for division, and then freeze. The chromosomes have already been duplicated, tetrads have been formed, and division has been delayed. They live in this form until the reproductive period. Then the eggs mature in turn, divide for the first time and freeze again. The second division occurs immediately after fertilization. And at this stage it is already difficult to control the quality of division. And the risks are greater, because the four chromosomes in the egg remain cross-linked for decades. During this time, damage accumulates in cohesins, and chromosomes can spontaneously separate. Therefore, the older the woman, the greater the likelihood of incorrect chromosome segregation in the egg.

Aneuploidy in germ cells inevitably leads to aneuploidy of the embryo. If a healthy egg with 23 chromosomes is fertilized by a sperm with extra or missing chromosomes (or vice versa), the number of chromosomes in the zygote will obviously be different from 46. But even if the sex cells are healthy, this does not guarantee healthy development. In the first days after fertilization, embryonic cells actively divide in order to quickly gain cell mass. Apparently, during rapid divisions there is no time to check the correctness of chromosome segregation, so aneuploid cells can arise. And if an error occurs, then the further fate of the embryo depends on the division in which it happened. If the balance is disturbed already in the first division of the zygote, then the entire organism will grow aneuploid. If the problem arose later, then the outcome is determined by the ratio of healthy and abnormal cells.

Some of the latter may continue to die, and we will never know about their existence. Or he can take part in the development of the organism, and then it will turn out mosaic- different cells will carry different genetic material. Mosaicism causes a lot of trouble for prenatal diagnosticians. For example, if there is a risk of having a child with Down syndrome, sometimes one or more cells of the embryo are removed (at a stage when this should not pose a danger) and the chromosomes in them are counted. But if the embryo is mosaic, then this method becomes not particularly effective.

Third wheel

All cases of aneuploidy are logically divided into two groups: deficiency and excess of chromosomes. The problems that arise with a deficiency are quite expected: minus one chromosome means minus hundreds of genes.

If the homologous chromosome works normally, then the cell can get away with only an insufficient amount of the proteins encoded there. But if some of the genes remaining on the homologous chromosome do not work, then the corresponding proteins will not appear in the cell at all.

In the case of an excess of chromosomes, everything is not so obvious. There are more genes, but here - alas - more does not mean better.

Firstly, excess genetic material increases the load on the nucleus: an additional strand of DNA must be placed in the nucleus and served by information reading systems.

Scientists have discovered that in people with Down syndrome, whose cells carry an extra 21st chromosome, the functioning of genes located on other chromosomes is mainly disrupted. Apparently, an excess of DNA in the nucleus leads to the fact that there are not enough proteins to support the functioning of the chromosomes for everyone.

Secondly, the balance in the amount of cellular proteins is disrupted. For example, if activator proteins and inhibitor proteins are responsible for some process in a cell, and their ratio usually depends on external signals, then an additional dose of one or the other will cause the cell to stop responding adequately to the external signal. Finally, an aneuploid cell has an increased chance of dying. When DNA is duplicated before division, errors inevitably occur, and the cellular repair system proteins recognize them, repair them, and start doubling again. If there are too many chromosomes, then there are not enough proteins, errors accumulate and apoptosis is triggered - programmed cell death. But even if the cell does not die and divides, then the result of such division will also most likely be aneuploids.

You will live

If even within one cell aneuploidy is fraught with malfunctions and death, then it is not surprising that it is not easy for an entire aneuploid organism to survive. At the moment, only three autosomes are known - 13, 18 and 21, trisomy for which (that is, an extra third chromosome in cells) is somehow compatible with life. This is likely due to the fact that they are the smallest and carry the fewest genes. At the same time, children with trisomy on the 13th (Patau syndrome) and 18th (Edwards syndrome) chromosomes live at best up to 10 years, and more often live less than a year. And only trisomy on the smallest chromosome in the genome, the 21st chromosome, known as Down syndrome, allows you to live up to 60 years.

People with general polyploidy are very rare. Normally, polyploid cells (carrying not two, but from four to 128 sets of chromosomes) can be found in the human body, for example, in the liver or red bone marrow. These are usually large cells with enhanced protein synthesis that do not require active division.

An additional set of chromosomes complicates the task of their distribution among daughter cells, so polyploid embryos, as a rule, do not survive. Nevertheless, about 10 cases have been described in which children with 92 chromosomes (tetraploids) were born and lived from several hours to several years. However, as in the case of other chromosomal abnormalities, they lagged behind in development, including mental development. However, many people with genetic abnormalities come to the aid of mosaicism. If the anomaly has already developed during the fragmentation of the embryo, then a certain number of cells may remain healthy. In such cases, the severity of symptoms decreases and life expectancy increases.

Gender injustices

However, there are also chromosomes, the increase in the number of which is compatible with human life or even goes unnoticed. And these, surprisingly, are sex chromosomes. The reason for this is gender injustice: approximately half of the people in our population (girls) have twice as many X chromosomes as others (boys). At the same time, the X chromosomes not only serve to determine sex, but also carry more than 800 genes (that is, twice as many as the extra 21st chromosome, which causes a lot of trouble for the body). But girls come to the aid of a natural mechanism for eliminating inequality: one of the X chromosomes is inactivated, twists and turns into a Barr body. In most cases, the choice occurs randomly, and in some cells the result is that the maternal X chromosome is active, while in others the paternal one is active. Thus, all girls turn out to be mosaic, because different copies of genes work in different cells. A classic example of such mosaicism is tortoiseshell cats: on their X chromosome there is a gene responsible for melanin (a pigment that determines, among other things, coat color). Different copies work in different cells, so the coloring is spotty and is not inherited, since inactivation occurs randomly.

As a result of inactivation, only one X chromosome always works in human cells. This mechanism allows you to avoid serious troubles with X-trisomy (XXX girls) and Shereshevsky-Turner syndrome (XO girls) or Klinefelter (XXY boys). About one in 400 children is born this way, but vital functions in these cases are usually not significantly impaired, and even infertility does not always occur. It is more difficult for those who have more than three chromosomes. This usually means that the chromosomes did not separate twice during the formation of sex cells. Cases of tetrasomy (ХХХХ, ХХYY, ХХХY, XYYY) and pentasomy (XXXXX, XXXXY, XXXYY, XXYYY, XYYYY) are rare, some of them have been described only a few times in the history of medicine. All of these options are compatible with life, and people often live to an advanced age, with abnormalities manifested in abnormal skeletal development, genital defects, and decreased mental abilities. Typically, the additional Y chromosome itself does not significantly affect the functioning of the body. Many men with the XYY genotype do not even know about their peculiarity. This is due to the fact that the Y chromosome is much smaller than the X and carries almost no genes that affect viability.

Sex chromosomes have another interesting feature. Many mutations of genes located on autosomes lead to abnormalities in the functioning of many tissues and organs. At the same time, most gene mutations on sex chromosomes manifest themselves only in impaired mental activity. It turns out that sex chromosomes largely control brain development. Based on this, some scientists hypothesize that they are responsible for the differences (however, not fully confirmed) between the mental abilities of men and women.

Who benefits from being wrong?

Despite the fact that medicine has been familiar with chromosomal abnormalities for a long time, recently aneuploidy continues to attract the attention of scientists. It turned out that more than 80% of tumor cells contain an unusual number of chromosomes. On the one hand, the reason for this may be the fact that proteins that control the quality of division are able to slow it down. In tumor cells, these same control proteins often mutate, so restrictions on division are lifted and chromosome checking does not work. On the other hand, scientists believe that this may serve as a factor in the selection of tumors for survival. According to this model, tumor cells first become polyploid, and then, as a result of division errors, they lose different chromosomes or parts thereof. This results in a whole population of cells with a wide variety of chromosomal abnormalities. Most are not viable, but some may succeed by chance, for example if they accidentally gain extra copies of genes that trigger division or lose genes that suppress it. However, if the accumulation of errors during division is further stimulated, the cells will not survive. The action of taxol, a common cancer drug, is based on this principle: it causes systemic chromosome nondisjunction in tumor cells, which should trigger their programmed death.

It turns out that each of us may be a carrier of extra chromosomes, at least in individual cells. However, modern science continues to develop strategies to deal with these unwanted passengers. One of them suggests using proteins responsible for the X chromosome and targeting, for example, the extra 21st chromosome of people with Down syndrome. It is reported that this mechanism was activated in cell cultures. So, perhaps, in the foreseeable future, dangerous extra chromosomes will be tamed and rendered harmless.

Polina Loseva

From school biology textbooks, everyone has become familiar with the term chromosome. The concept was proposed by Waldeyer in 1888. It literally translates as painted body. The first object of research was the fruit fly.

General information about animal chromosomes

A chromosome is a structure in the cell nucleus that stores hereditary information. They are formed from a DNA molecule that contains many genes. In other words, a chromosome is a DNA molecule. Its amount varies among different animals. So, for example, a cat has 38, and a cow has 120. Interestingly, earthworms and ants have the smallest numbers. Their number is two chromosomes, and the male of the latter has one.

In higher animals, as well as in humans, the last pair is represented by XY sex chromosomes in males and XX in females. It should be noted that the number of these molecules is constant for all animals, but their number differs in each species. For example, we can consider the content of chromosomes in some organisms: chimpanzees - 48, crayfish - 196, wolves - 78, hare - 48. This is due to the different level of organization of a particular animal.

Note! Chromosomes are always arranged in pairs. Geneticists claim that these molecules are the elusive and invisible carriers of heredity. Each chromosome contains many genes. Some believe that the more of these molecules, the more developed the animal, and the more complex its body is. In this case, a person should have not 46 chromosomes, but more than any other animal.

How many chromosomes do different animals have?

You need to pay attention! In monkeys, the number of chromosomes is close to that of humans. But the results are different for each species. So, different monkeys have the following number of chromosomes:

• Lemurs have 44-46 DNA molecules in their arsenal;
• Chimpanzees – 48;
• Baboons – 42,
• Monkeys – 54;
• Gibbons – 44;
• Gorillas – 48;
• Orangutan – 48;
• Macaques - 42.

The canine family (carnivorous mammals) has more chromosomes than monkeys.

• So, the wolf has 78,
• the coyote has 78,
• the small fox has 76,
• but the ordinary one has 34.
• The predatory animals lion and tiger have 38 chromosomes.
• The cat's pet has 38, while his dog opponent has almost twice as many - 78.

In mammals that are of economic importance, the number of these molecules is as follows:

• rabbit – 44,
• cow – 60,
• horse – 64,
• pig – 38.

Educational! Hamsters have the largest chromosome sets among animals. They have 92 in their arsenal. Also in this row are hedgehogs. They have 88-90 chromosomes. And kangaroos have the smallest amount of these molecules. Their number is 12. A very interesting fact is that the mammoth has 58 chromosomes. Samples were taken from frozen tissue.

For greater clarity and convenience, data from other animals will be presented in the summary.

Name of animal and number of chromosomes:

Number of chromosomes in different animal species

As you can see, each animal has a different number of chromosomes. Even among representatives of the same family, indicators differ. We can look at the example of primates:

• the gorilla has 48,
• the macaque has 42, and the marmoset has 54 chromosomes.

Why this is so remains a mystery.

How many chromosomes do plants have?

Plant name and number of chromosomes:

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